IGF-1 LR3 (insulin-like growth factor-1 long arginine 3) is a synthetic, modified construct of insulin-like growth factor-1. Because IGF-1 LR3 does not bind to IGF-1 binding proteins very well, it remains active up to 120 times longer than standard IGF-1. This results in improved half-life for the peptide and thus increased activity. IGF-1 LR3 enhances cell division and growth, boosts fat metabolism, and increases muscle repair and hypertrophy by inhibiting myostatin. Recent research suggests that IGF-1 LR3 may also be useful in improving lactation among mothers with young offspring.
Research
There are several scientific studies related to IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) peptide, including the following:
Long R3 IGF-I (IGF-1)
Published in the Journal of Exercise Science & Fitness in 2008, this study discusses the pharmacokinetics and pharmacodynamics of Long R3 IGF-I.
The Role of Insulin-like Growth Factor 1 (IGF-1) in Skeletal Muscle Hypertrophy and Differentiation
Published in the Journal of Molecular Medicine in 2015, this review article examines the role of IGF-1 in skeletal muscle hypertrophy and differentiation.
Effects of Long R3 Insulin-like Growth Factor-I on Cardiomyocyte Development in Murine Embryonic Stem Cells
Published in the Endocrinology journal in 2002, this study investigates the effects of Long R3 IGF-I on cardiomyocyte development in murine embryonic stem cells.
Growth hormone/IGF-I axis in neurodegenerative diseases
Published in the Ageing Research Reviews journal in 2013, this review article discusses the involvement of the growth hormone/IGF-I axis in neurodegenerative diseases.
Effects of long R3 IGF-I on the osteogenic differentiation of human amniotic fluid-derived stem cells
Published in the Growth Factors journal in 2013, this study examines the effects of Long R3 IGF-I on the osteogenic differentiation of human amniotic fluid-derived stem cells.
These studies provide insights into the potential biological effects and therapeutic applications of IGF-1 LR3 peptide, particularly in muscle growth, cardiomyocyte development, neurodegenerative diseases, and osteogenic differentiation in animals.
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